![]() ![]() In order to overcome those objections the mixture of sodium lactate and hypotonic Ringer’s solution was devised. …if sodium bicarbonate were properly administered along with other indicated therapeutic measures, severe acidosis could be much more effectively treated…however, if given intravenously in amounts large enough to insure effectiveness, it tended to produce too rapid a change in the reaction of the body fluids, and often resulted in an almost immediate shift from uncompensated acidosis to uncompensated alkalosis. The process of sterilisation was laborious the solution was highly irritant and made administration difficult and sodium bicarbonate administration often produced too rapid a correction of the acidosis potentially resulting in a profound alkalosis.Īn alternative to sodium bicarbonate was needed: In the 1930’s there were several problems complicating the use of sodium bicarbonate to treat acidosis. His research work centred around treating acidosis in sick children. Ringer 1883Īlexis Frank Hartmann (1898-1964) was an American pediatrician and clinical biochemist. ![]() The ability of a small volume of Ringer solution to sustain an excised frog heart-nerve preparation enabled Otto Loewi and Sir Henry Hallett Dale to propose the chemical transmission of nerve impulses For this, Loewi and Dale received the 1936 Nobel Prize in Physiology or Medicine.Ī mixture containing 100cc saline, 5cc sodium bicarbonate, 5cc calcium chloride, with 1 cc potassium chloride makes an excellent artificial circulating fluid, for with this mixture the heart will continue beating perfectly. It is obvious therefore, that the effects I had obtained are due to some of the inorganic constituents of the pipe water. As this water contains minute traces of various inorganic substances, I at once tested the action of saline solution made with distilled water and I found that I did not get the effects described in the paper referred to. I discovered, that the saline solution which I had used had not been prepared with distilled water, but with pipe water supplied by the New River Water Company. Ringer noticed that the experiments with tap water yielded different results from those with distilled water he deduced this was due to the fact tap water contained inorganic substances. Ringer’s lab assistant mistakenly substituted tap water for distilled water, in experiments they were performing on frogs hearts. The discovery of Ringers solution was an accident. In 1882 discovered a solution of salts dissolved in water to create an isotonic solution relative to the body fluids of an animal. In particular the actions of various inorganic salts on the behaviour of the heart. He studied the effects of electrolytes on cardiac and involuntary muscles. Sydney Ringer (1835-1910) was a British clinician, physiologist and pharmacologist. History of Hartmann’s solution or Ringer’s lactate ![]()
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